Description

Azasetron Hydrochloride is a potent and selective serotonin 5-HT3 receptor antagonist, a critical active pharmaceutical ingredient (API) in the treatment of nausea and vomiting, particularly associated with chemotherapy. Its high selectivity ensures effective antiemetic action with a favorable side-effect profile, making it a valuable component in pharmaceutical formulations. This compound is essential for manufacturers in the pharmaceutical industry developing injectable and oral dosage forms for oncological and postoperative care.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic medications.
• Chemotherapy-Induced Nausea and Vomiting (CINV): Formulation into injectable solutions for the prevention and treatment of acute and delayed CINV.
• Postoperative Nausea and Vomiting (PONV): Used in clinical settings to manage nausea following surgical procedures.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research and new drug development.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic antiemetic drugs.
• Formulation Development: Used in stability studies and the development of various dosage forms including tablets and lyophilized powders.

Basic Information

Product Name	Azasetron Hydrochloride
CAS No.	123040-94-8
Molecular Formula	C17H20N4O2 • HCl
Molecular Weight	356.83 g/mol
Synonyms	Azasetron HCl; Y-25130; (±)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride; 6-Chloro-4-methyl-3-oxo-N-(3-quinuclidinyl)-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride; Y 25130; Y25130
EINECS	Contact for details

Quality Control

Our Azasetron Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.