Description

Azasetron Hydrochloride is a potent and selective 5-HT3 receptor antagonist, a critical active pharmaceutical ingredient (API) in the management of chemotherapy-induced nausea and vomiting (CINV). Its high selectivity ensures effective antiemetic action with a favorable side-effect profile, making it a valuable component in oncology support therapies. This compound is essential for pharmaceutical manufacturers developing injectable and oral formulations aimed at improving patient quality of life during cancer treatment. The product is supplied under stringent quality controls to meet the exacting standards of the global pharmaceutical industry.

Application

• Primary Active Pharmaceutical Ingredient (API) in antiemetic injectable solutions.
• Key component in the formulation of oral tablets and capsules for nausea prevention.
• Used in clinical research and development of new 5-HT3 receptor antagonist therapies.
• Critical for the production of generic oncology support medications.
• Employed in combination therapy regimens for enhanced control of post-operative nausea and vomiting (PONV).
• Utilized in the synthesis of reference standards for analytical and quality control laboratories.

Basic Information

Item	Detail
Product Name	Azasetron Hydrochloride
CAS No.	123040-69-7
Molecular Formula	C19H23N3O2·HCl
Molecular Weight	353.87 g/mol
Synonyms	Azasetron HCl; Y-25130; (±)-N-(1-Azabicyclo[2.2.2]oct-8-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride; 6-Chloro-3,4-dihydro-4-methyl-3-oxo-N-(8-quinuclidinyl)-2H-1,4-benzoxazine-8-carboxamide monohydrochloride; 1,4-Benzoxazine-8-carboxamide, 6-chloro-3,4-dihydro-4-methyl-3-oxo-N-(8-quinuclidinyl)-, monohydrochloride
EINECS	Contact for details

Quality Control

Every batch of Azasetron Hydrochloride is manufactured under a cGMP-compliant quality management system. Our products undergo rigorous analytical testing, including HPLC, IR, and residual solvent analysis, to ensure high purity and consistency that meets or exceeds pharmacopeial standards. Comprehensive Certificates of Analysis (COA) documenting identity, assay, impurities, and other critical parameters are available upon request to support your regulatory filings and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.