Description

n-Succinimidyl 3-(Trimethylstannyl)Benzoate is a specialized organotin reagent featuring a reactive N-hydroxysuccinimide (NHS) ester group. This compound is critically important for its role as a versatile intermediate in the synthesis of bioconjugates and radiolabeled compounds, particularly for medical imaging and targeted drug delivery research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of diagnostic agents and novel therapeutics.

Application

• Radiopharmaceutical Precursor: A key intermediate in the synthesis of PET (Positron Emission Tomography) imaging agents, where the tin moiety can be used for isotopic exchange with radioactive iodine (e.g., I-124, I-131).
• Bioconjugation Chemistry: Used to introduce the 3-(trimethylstannyl)benzoyl group into biomolecules like antibodies, peptides, or proteins via its amine-reactive NHS ester, creating a site for subsequent radiolabeling.
• Organic Synthesis Building Block: Serves as a valuable stannylated aryl reagent in cross-coupling reactions, such as Stille couplings, to construct complex molecular architectures.
• Diagnostic Probe Development: Enables the creation of targeted diagnostic probes for cancer and other diseases by facilitating the attachment of imaging isotopes to targeting vectors.
• Research & Development: Essential for academic and industrial R&D labs exploring new radiolabeling methodologies and theranostic (therapy + diagnostic) agents.

Basic Information

Product Name	n-Succinimidyl 3-(Trimethylstannyl)Benzoate
CAS No.	122856-01-3
Molecular Formula	C15H19NO4Sn
Molecular Weight	396.02 g/mol
Synonyms	3-(Trimethylstannyl)benzoic acid N-succinimidyl ester; 3-(Trimethylstannyl)benzoic acid succinimidyl ester; NHS ester of 3-(Trimethylstannyl)benzoic acid; S-3-TMB-NHS; N-Succinimidyl 3-(trimethylstannyl)benzoate; 1-[(3-Trimethylstannyl)benzoyloxy]pyrrolidine-2,5-dione; 2,5-Dioxopyrrolidin-1-yl 3-(trimethylstannyl)benzoate
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 3-(Trimethylstannyl)Benzoate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive radiochemistry applications. Each lot is characterized by NMR (1H, 13C) and HPLC analysis to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maximize shelf life and prevent degradation of the reactive NHS ester and the organotin moiety. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.