Description

n-(4-(3-Oxo-6-Amino-2,3-Dihydro-1,2,4-Benzotriazin-2-Yl)Benzoyl)Glutamic Acid is a high-purity, non-natural amino acid derivative featuring a benzotriazinone pharmacophore, making it a compound of significant interest for advanced research and development. Its molecular architecture is specifically designed to serve as a critical building block or a potential active pharmaceutical ingredient (API) intermediate in targeted therapeutic applications. This compound is essential for pharmaceutical chemists, biochemists, and research institutions focused on oncology, enzyme inhibition, and novel drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or a core scaffold in the development of novel small-molecule drugs, particularly in oncology research.
• Biochemical Research: Used as a specialized reagent or substrate in enzymatic studies and proteomics research due to its unique glutamic acid-linked heterocyclic structure.
• Antifolate Agent Development: Investigated for its potential role in the design of novel antifolate compounds targeting dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying protein-ligand interactions and cellular signaling pathways.
• Precision Medicine: Acts as a candidate structure for the development of targeted therapies and personalized medicine approaches.
• Academic & Institutional R&D: Employed in university and institutional laboratories for fundamental research in medicinal chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	n-(4-(3-Oxo-6-Amino-2,3-Dihydro-1,2,4-Benzotriazin-2-Yl)Benzoyl)Glutamic Acid
CAS No.	122712-57-6
Molecular Formula	C19H17N5O6
Molecular Weight	411.37 g/mol
Synonyms	2-[[4-(6-Amino-3-oxo-2,3-dihydro-1,2,4-benzotriazin-2-yl)benzoyl]amino]pentanedioic acid; L-Glutamic acid, N-[4-(6-amino-3-oxo-2,3-dihydro-1,2,4-benzotriazin-2-yl)benzoyl]-; (2S)-2-[[4-(6-Amino-3-oxo-1H-1,2,4-benzotriazin-2-yl)benzoyl]amino]pentanedioic acid; AGT Inhibitor Intermediate; Benzotriazinone-glutamate conjugate
EINECS	Contact for details

Quality Control

Our n-(4-(3-Oxo-6-Amino-2,3-Dihydro-1,2,4-Benzotriazin-2-Yl)Benzoyl)Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and comprehensive impurity profiling. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade and potential cGMP standards for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.