Description

9-Methyl-10-Deazaminopterin is a high-purity synthetic folate analog with significant biochemical activity. This compound is valued for its role as a potent inhibitor of dihydrofolate reductase (DHFR), making it a critical intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, metabolic pathway studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced antifolate chemotherapeutic agents.
• Biochemical Research: Used as a potent reference standard and inhibitor in enzymatic studies targeting dihydrofolate reductase (DHFR).
• Oncology Drug Discovery: Serves as a core scaffold for developing novel anticancer compounds targeting folate metabolism.
• Academic Research: Employed in university and institutional labs for studying cell proliferation, nucleotide synthesis, and metabolic pathways.
• Reference Material: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	9-Methyl-10-Deazaminopterin
CAS No.	122594-35-8
Molecular Formula	C₂₀H₂₃N₇O₅
Molecular Weight	441.44 g/mol
Synonyms	10-Deaza-9-methylaminopterin; 9-Methyl-10-deazaaminopterin; NSC 740; (2-{4-[(2,4-Diamino-6-pteridinyl)methyl]methylamino}benzoyl)amino)pentanedioic acid; 9-Methyl-10-DAM; Pteridine analog; Antifolate analog; DHFR inhibitor
EINECS	Contact for details

Quality Control

Our 9-Methyl-10-Deazaminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.