Description

5-Azidouridine 5'-Diphosphoglucose is a specialized nucleotide sugar derivative, chemically modified with an azido group for advanced biochemical applications. This compound serves as a critical biochemical tool, enabling precise metabolic labeling and click chemistry-based studies of glycosylation pathways. It is primarily utilized by research scientists and pharmaceutical developers in the fields of chemical biology, glycobiology, and drug discovery to investigate and manipulate cellular processes.

Application

• Metabolic Glycan Labeling: Acts as a bioorthogonal metabolic precursor for tagging and visualizing glycoconjugates in living cells via click chemistry.
• Glycobiology Research: Used to study the biosynthesis, function, and trafficking of glycoproteins and glycolipids.
• Enzyme Activity Assays: Serves as a substrate or inhibitor for glycosyltransferases and other carbohydrate-active enzymes.
• Chemical Probe Development: Integral to creating activity-based probes for profiling enzyme families involved in nucleotide sugar metabolism.
• Drug Discovery Platforms: Employed in high-throughput screening assays to identify novel inhibitors of glycosylation pathways relevant to cancer and infectious diseases.
• Bioconjugation: The azido moiety facilitates site-specific conjugation of sugars to proteins, antibodies, or surfaces for diagnostic and therapeutic applications.

Basic Information

Product Name	5-Azidouridine 5'-Diphosphoglucose
CAS No.	122060-70-2
Molecular Formula	C15H22N6O17P2
Molecular Weight	644.32 g/mol
Synonyms	5-Azido-UDP-glucose; UDP-5-azidouridine glucose; Uridine 5'-(trihydrogen diphosphate), P'→5'-ester with 5-azido-1-β-D-ribofuranosyluracil; 5-Azido-UDPG; 5-N3-UDP-Glc; Azido-UDP-sugar; 5-Azidouridine diphosphate glucose
EINECS	Contact for details

Quality Control

Our 5-Azidouridine 5'-Diphosphoglucose is manufactured under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability, consistency, and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.