Description

12,13-Dihydroxy-5,8,10,14-Eicosatetraenoic Acid is a bioactive eicosanoid derivative, specifically a dihydroxy fatty acid, that plays a significant role in cellular signaling pathways. This compound is valued for its function as a key intermediate in the biosynthesis of specialized pro-resolving mediators (SPMs) and other oxylipins involved in the regulation of inflammation and immune responses. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for biochemical research, drug discovery, and the development of novel therapeutic agents targeting inflammatory diseases.

Application

• Biochemical Research: Used as a critical reference standard and intermediate in studies of eicosanoid metabolism, lipid signaling, and inflammation resolution pathways.
• Pharmaceutical Development: Serves as a key starting material or intermediate in the synthesis of novel anti-inflammatory compounds and specialized pro-resolving mediators (SPMs).
• Cell Biology Studies: Employed in in vitro and in vivo models to investigate cellular responses, receptor interactions, and signal transduction mechanisms.
• Analytical Standard: Essential for method development, calibration, and quantification in analytical techniques like HPLC and LC-MS/MS for lipidomics research.
• Enzyme Activity Assays: Used as a substrate to study the activity and inhibition of enzymes such as lipoxygenases and cytochrome P450s involved in arachidonic acid metabolism.

Basic Information

Product Name	12,13-Dihydroxy-5,8,10,14-Eicosatetraenoic Acid
CAS No.	121979-37-1
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	12,13-DiHETE; (5Z,8Z,10E,14Z)-(12S,13S)-12,13-Dihydroxyeicosa-5,8,10,14-tetraenoic acid; 12(S),13(S)-DiHETE; 12,13-Dihydroxyeicosatetraenoic acid; 12,13-DiHETrE; 12,13-DHETE; 12,13-Dihydroxy-5Z,8Z,10E,14Z-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our 12,13-Dihydroxy-5,8,10,14-Eicosatetraenoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.