Description

Eicosapentaenoic Acid-Coenzyme A is a high-purity, activated biochemical conjugate essential for advanced lipid metabolism research and biopharmaceutical development. This specialized coenzyme A derivative is critical for studying and modulating the biosynthesis of eicosanoids and other bioactive lipid mediators derived from ω-3 fatty acids. It serves as a vital reagent for researchers and manufacturers in pharmaceutical R&D, metabolic pathway analysis, and the production of high-value reference standards and diagnostic kits.

Application

• Enzymatic Research & Assay Development: As a key substrate for studying the activity and kinetics of acyl-CoA synthetases, elongases, and desaturases involved in the ω-3 metabolic pathway.
• Biochemical Reference Standard: For the qualification and quantification of EPA-CoA and related metabolites in complex biological matrices using LC-MS/MS and other analytical techniques.
• Pharmaceutical Intermediates: In the synthesis of novel therapeutic agents targeting inflammatory pathways, cardiovascular diseases, and neurological disorders linked to lipid metabolism.
• Cell Culture & In Vitro Studies: For supplementing media to investigate the direct effects of activated EPA on cellular signaling, gene expression, and membrane fluidity.
• Diagnostic Kit Manufacturing: As a critical component in enzymatic assays designed to measure specific metabolic enzyme deficiencies or activity levels in clinical diagnostics.
• Metabolomics & Lipidomics: Enabling precise tracing and profiling of eicosapentaenoic acid incorporation into complex lipid species within metabolic flux studies.

Basic Information

Product Name	Eicosapentaenoic Acid-Coenzyme A
CAS No.	121935-04-4
Molecular Formula	C₄₂H₇₀N₇O₁₇P₃S
Molecular Weight	1102.0 g/mol (approx.)
Synonyms	EPA-CoA; Eicosapentaenoyl-Coenzyme A; all-cis-5,8,11,14,17-Eicosapentaenoyl-CoA; (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoyl-Coenzyme A; Arachidonic Acid-CoA (related); CoA-EPA; ω-3 Fatty Acyl-Coenzyme A; Activated Eicosapentaenoic Acid
EINECS	Contact for details

Quality Control

Our Eicosapentaenoic Acid-Coenzyme A is produced under stringent conditions to ensure batch-to-batch consistency and high biochemical activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and assay, NMR and MS for structural confirmation, and enzymatic activity validation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, identity, and specific performance characteristics. Our quality system supports compliance with cGMP standards for research and pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to molecular ion pattern
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Enzymatic/UV)	≥ 90% (by A260, Molar Extinction Coefficient)
Water Content (KF)	≤ 5.0% w/w
Solubility	Clear, colorless solution in water or buffer
Biological Activity	Confirmed via specific enzymatic coupling assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.