Description

2-(2-Azido-4-Nitrobenzoyl)-1-Myristoylglycero-3-Phosphoethanolamine is a specialized, high-purity phospholipid derivative designed for advanced biochemical research and development. This compound is critical for applications requiring photoactivatable or crosslinking lipid probes due to its integrated azido and nitrobenzoyl functional groups. It is primarily utilized by researchers and product developers in the pharmaceutical, biotechnology, and life science sectors for membrane studies, targeted drug delivery systems, and proteomic analysis.

Application

• Photoaffinity Labeling: Used as a critical reagent in photoaffinity labeling studies to investigate protein-lipid interactions and membrane protein topology.
• Liposome & Nanoparticle Functionalization: Serves as a key component for constructing targeted drug delivery vehicles, such as liposomes and lipid nanoparticles (LNPs), enabling surface modification and ligand conjugation.
• Membrane Biophysics Research: Employed in model membrane systems (e.g., liposomes, supported lipid bilayers) to study lipid dynamics, membrane fluidity, and domain formation.
• Proteomics & Crosslinking Mass Spectrometry (XL-MS): Acts as a crosslinking probe for identifying and mapping transient or weak interactions between lipids and proteins within cellular membranes.
• Bioconjugation & Click Chemistry: The azide group allows for efficient, bioorthogonal conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) reactions.
• Diagnostic Assay Development: Incorporated into the design of biosensors and diagnostic assays that require specific membrane anchoring or signal amplification.

Basic Information

Product Name	2-(2-Azido-4-Nitrobenzoyl)-1-Myristoylglycero-3-Phosphoethanolamine
CAS No.	121888-03-7
Molecular Formula	C32H52N5O11P
Molecular Weight	713.76 g/mol
Synonyms	1-Myristoyl-2-[2-(azido)-4-nitrobenzoyl]-sn-glycero-3-phosphoethanolamine; N-(2-Azido-4-nitrobenzoyl)-1-myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine; Azido Nitrobenzoyl Phosphoethanolamine Lipid; ANB-PE; Photoactivatable PE Lipid; Crosslinking Phospholipid; 2-ANB-PE; N-[2-(2-Azido-4-nitrobenzoyloxy)ethyl]-1-myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Azido-4-Nitrobenzoyl)-1-Myristoylglycero-3-Phosphoethanolamine is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We ensure high purity and batch-to-batch consistency through techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere (e.g., argon or nitrogen) to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.