Description

6-(4-Bromoacetamidobenzyl)-1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-Tetraacetic Acid is a bifunctional chelating agent that combines a bromoacetamide reactive group with a macrocyclic tetraazacyclotetradecane tetraacetic acid (TETA) backbone. This compound is critically important for creating stable, site-specific conjugates between biomolecules and radiometals for diagnostic and therapeutic applications. It is primarily utilized by researchers and manufacturers in radiopharmaceutical development, molecular imaging, and targeted radiotherapy.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling antibodies, peptides, and other targeting vectors with therapeutic or diagnostic radiometals like copper-64, gallium-67/68, and yttrium-90.
• Molecular Imaging Probes: Used in the synthesis of contrast agents for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) to visualize disease biomarkers.
• Targeted Radionuclide Therapy (TRT): Enables the development of radioconjugates for delivering cytotoxic radiation directly to cancer cells while minimizing damage to healthy tissue.
• Research & Development: Serves as a key intermediate in academic and industrial labs for studying chelation chemistry, metal complex stability, and new drug delivery platforms.
• Theragnostic Agent Development: Facilitates the creation of paired diagnostic/therapeutic (theragnostic) agents using matched pairs of radioisotopes (e.g., Cu-64 for imaging and Cu-67 for therapy).
• Bioconjugation Chemistry: The bromoacetamide group allows for selective covalent attachment to thiol (-SH) groups on proteins and other biomolecules under mild conditions.

Basic Information

Product Name	6-(4-Bromoacetamidobenzyl)-1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-Tetraacetic Acid
CAS No.	121697-38-9
Molecular Formula	C26H38BrN5O10
Molecular Weight	660.52 g/mol
Synonyms	p-Bromoacetamidobenzyl-TETA; BnBrA-TETA; 6-[4-(Bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid; 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid, 6-[(4-bromoacetyl)amino]benzyl]-; BnBrA-cyclam tetraacetic acid; Bromoacetamidobenzyl-DOTA analogue (TETA variant); Bifunctional Chelator TETA-BrA
EINECS	Contact for details

Quality Control

Our production of this high-value chelator adheres to stringent quality protocols suitable for research and pre-clinical development. Every batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and structural confirmation via NMR and Mass Spectrometry. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters to ensure batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.