Description

o-Tresyl-O'-Methylpolyethylene Glycol 5'000* is a high-purity, functionalized polyethylene glycol derivative featuring a reactive tresyl group at one terminus and a methoxy-capped PEG chain. This compound is engineered to serve as a critical heterobifunctional linker for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined constructs. It is essential for researchers and manufacturers in the fields of bioconjugation, advanced drug delivery systems, and the development of diagnostic reagents who require reliable, high-quality PEGylation reagents.

Application

• Bioconjugation and PEGylation: Site-specific modification of proteins, peptides, and antibodies to enhance solubility, stability, and pharmacokinetic profiles.
• Drug Delivery Systems: Synthesis of targeted drug conjugates and prodrugs, particularly for creating long-circulating nanomedicines.
• Surface Functionalization: Immobilization of biomolecules onto solid supports (e.g., biosensors, microarrays, and chromatography media) via the reactive tresylate group.
• Crosslinking Agent: Used in the preparation of hydrogels and polymer networks for biomedical and material science applications.
• Diagnostic Reagent Development: Conjugation of enzymes, fluorescent dyes, or other reporter molecules to antibodies or other targeting moieties.
• Lipid Nanoparticle (LNP) Formulation: Functionalization of lipid components to improve targeting and stealth properties in mRNA and siRNA delivery systems.

Basic Information

Product Name	o-Tresyl-O'-Methylpolyethylene Glycol 5'000*
CAS No.	121559-53-3
Molecular Formula	CnH2n+2O(n+1) (CH3O-PEG-OTs) *Typical for PEG derivatives
Molecular Weight	~5,000 g/mol (nominal)
Synonyms	mPEG-Tresylate; Methoxy PEG Tresylate; α-Methoxy-ω-tresylpoly(ethylene glycol); Poly(ethylene glycol) methyl ether 2-[(methylsulfonyl)oxy]ethyl ether; PEG-OTs; Tresyl-PEG-OMe; Tresylated mPEG; O-(2-((Methylsulfonyl)oxy)ethyl)-O'-methylpolyethylene glycol
EINECS	Contact for details

Quality Control

Our o-Tresyl-O'-Methylpolyethylene Glycol 5'000* is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) detailing specifications such as NMR purity, degree of substitution, and residual solvent levels are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., argon or nitrogen) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Nominal Molecular Weight	5,000 Da
Purity (NMR)	≥ 95%
Degree of Substitution	≥ 90%
Polydispersity Index (PDI)	≤ 1.05
Moisture (KF)	≤ 1.0%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.