Description

32-Carboxycyanocobalamin is a chemically modified derivative of Vitamin B12 (cyanocobalamin), distinguished by the presence of a carboxyl group at the 32-position of the corrin ring. This modification is critical for advanced biochemical research and the synthesis of specialized cobalamin analogs used in studying enzyme mechanisms and metabolic pathways. It serves as a key intermediate and reference standard for pharmaceutical R&D, analytical laboratories, and manufacturers of high-purity biochemical reagents targeting the life sciences sector.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay validation of Vitamin B12 and related compounds in drug formulations.
• Biochemical Research Intermediate: Serves as a crucial precursor in the synthesis of novel cobalamin derivatives for studying B12-dependent enzymes like methionine synthase and methylmalonyl-CoA mutase.
• Metabolic Pathway Studies: Employed in tracer studies and analytical methods to investigate Vitamin B12 absorption, transport, and cellular metabolism.
• Diagnostic Reagent Manufacturing: Utilized in the production of key components for clinical diagnostic kits that measure Vitamin B12 levels in serum.
• Nutritional Science Research: Acts as a model compound for researching the stability, bioavailability, and functional properties of modified B12 vitamins.
• Analytical Method Development: Provides a high-purity standard for developing and calibrating advanced analytical techniques such as HPLC-MS and LC-MS/MS in food and pharmaceutical analysis.

Basic Information

Product Name	32-Carboxycyanocobalamin
CAS No.	121483-62-3
Molecular Formula	C₆₄H₈₈CoN₁₄O₁₇P
Molecular Weight	1404.3 g/mol
Synonyms	32-Carboxycyanocobalamin; Vitamin B12 32-carboxylic acid; 32-COOH-Cyanocobalamin; Cyanocobalamin-32-carboxylic acid; Coβ-[(α-5,6-dimethylbenzimidazolyl)]-Coα-(cyanocobalamin-32-carboxylate); 32-Carboxycobalamin; (32-Carboxy-5,6-dimethylbenzimidazolyl)cyanocobamide
EINECS	Contact for details

Quality Control

Our 32-Carboxycyanocobalamin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and related substance profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Dark red crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (UV-Vis)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (Karl Fischer)	≤ 5.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.