Description

1,2-Distearoyl-3-Dimethylammonium-Propane is a synthetic, cationic lipid widely utilized as a key component in advanced formulation science. Its primary value lies in its ability to form stable, positively charged liposomes and lipid nanoparticles, which are essential for the efficient encapsulation and delivery of sensitive or charged molecules. This makes it a critical material for researchers and manufacturers in the pharmaceutical, biotechnology, and gene therapy sectors, particularly for developing non-viral transfection reagents and novel drug delivery systems.

Application

• As a critical cationic lipid component in the formulation of liposomal and lipid nanoparticle (LNP) drug delivery systems.
• Primary use in the preparation of non-viral transfection reagents for introducing nucleic acids (DNA, siRNA, mRNA) into cells in vitro and in vivo.
• Key excipient in the development of mRNA vaccines and therapeutics, where it facilitates cellular uptake and endosomal escape.
• Used in gene therapy research for the encapsulation and protection of genetic material.
• Component in cationic lipid-based adjuvants for vaccine development.
• Research applications in membrane biophysics and the study of lipid bilayer properties.
• Potential use in cosmetic formulations requiring cationic charge for conditioning and stabilization.
• As a phase transfer catalyst or surfactant in specialized organic synthesis due to its amphiphilic structure.

Basic Information

Product Name	1,2-Distearoyl-3-Dimethylammonium-Propane
CAS No.	121315-93-3
Molecular Formula	C41H84N+O4
Molecular Weight	654.12 g/mol
Synonyms	DSPC (Cationic); 1,2-Distearoyl-sn-glycero-3-ethylphosphocholine (common misnomer); 1,2-Di-O-octadecanoyl-3-O-(trimethylammonio)propyl-rac-glycerol; DSDAP; 1,2-Distearoyl-rac-glycero-3-ethylphosphocholine; Cationic lipid 18:0; (2,3-Bis(octadecanoyloxy)propyl)trimethylazanium; CL-18:0/18:0
EINECS	Contact for details

Quality Control

Our 1,2-Distearoyl-3-Dimethylammonium-Propane is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive biological applications. Each lot undergoes comprehensive analytical testing including HPLC for purity and related substances, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, assay, impurity profile, and residual solvents is provided with every shipment. We support compliance with cGMP guidelines for advanced therapeutic medicinal product (ATMP) development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. For long-term storage, desiccate at -20°C. The product is light-sensitive and easily oxidized; allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Phase Transition Temperature (DSC)	Reported value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.