Description

Loxoribine is a synthetic guanosine ribonucleoside analog known for its potent immunomodulatory properties. This compound is a critical intermediate and active ingredient in advanced pharmaceutical research, particularly in the development of novel immunotherapies and vaccine adjuvants. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors focused on modulating immune responses.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced immunomodulatory drugs.
• Immunology Research: Used as a toll-like receptor 7 (TLR7) agonist to study innate immune system activation and signaling pathways.
• Vaccine Adjuvant Development: Investigated for enhancing the efficacy of vaccines by stimulating a stronger immune response.
• Oncology Research: Employed in preclinical studies for cancer immunotherapy to potentiate anti-tumor immune activity.
• Antiviral Agent Research: Studied for its potential activity against viral infections due to its immune-stimulating effects.
• Biochemical Standard: Serves as a reference standard in analytical laboratories for quality control and method development.

Basic Information

Product Name	Loxoribine
CAS No.	121288-39-9
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	7-Allyl-8-oxoguanosine; 7-Allyl-8-oxo-guanosine; 8-Oxo-7-allylguanosine; Loxoribine; 7-Allyl-8-hydroxyguanosine; 7-Allyl-8-oxoguanosine (Loxoribine); TLR7 Agonist Loxoribine; 1,9-Dihydro-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-(prop-2-en-1-yl)-3H-purine-2,6,8-trione
EINECS	Contact for details

Quality Control

Our Loxoribine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.