Description

n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Guanosine Phosphoramidite is a high-purity, chemically modified nucleoside phosphoramidite building block essential for solid-phase oligonucleotide synthesis. This compound is specifically engineered to provide orthogonal protection for the 2'-hydroxyl group, enabling the synthesis of complex RNA and chimeric oligonucleotides with precise control. It is a critical raw material for research institutions, diagnostic developers, and pharmaceutical companies engaged in the development of antisense therapeutics, siRNA, aptamers, and other advanced nucleic acid-based technologies.

Application

• Solid-Phase Oligonucleotide Synthesis: A key monomer for the automated synthesis of RNA strands and RNA-DNA chimeras on DNA/RNA synthesizers.
• Therapeutic Oligonucleotide R&D: Production of research-grade and pre-clinical siRNA, antisense oligonucleotides (ASOs), and microRNA mimics for drug discovery programs.
• Diagnostic Probe Manufacture: Synthesis of labeled and modified RNA probes used in molecular diagnostics, FISH assays, and biosensor development.
• Aptamer and Ribozyme Synthesis: Building block for creating functional nucleic acids (aptamers, ribozymes, DNAzymes) used in biotechnology and synthetic biology.
• Academic and Industrial Research: Fundamental research tool for studying RNA structure, function, and RNA-protein interactions.

Basic Information

Item	Details
Product Name	n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Guanosine Phosphoramidite
CAS No.	121058-87-5
Molecular Formula	C₄₇H₅₄FN₄O₁₀P
Molecular Weight	884.92 g/mol
Synonyms	2'-O-(1-Fluoroprop-2-yl)-5'-O-(4,4'-dimethoxytrityl)guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Guanosine, 2'-O-[1-(fluoromethyl)-2-propanyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-[(2-cyanoethyl) diisopropylphosphoramidite]; 2'-O-Fpmp-Guanosine-3'-phosphoramidite; 5'-O-DMT-2'-O-FPMP-G-CE Phosphoramidite; Fpmp-protected Guanosine Phosphoramidite; RNA Phosphoramidite Monomer (G); Ced Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of our n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Guanosine Phosphoramidite is manufactured and tested under strict quality management systems to ensure consistency and reliability for critical synthesis workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and moisture content. Our quality protocols are designed to meet the exacting standards required for pharmaceutical R&D and GMP-grade production of oligonucleotides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition and reduced coupling efficiency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (³¹P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Moisture Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.