Description

Nelarabine is a purine nucleoside antimetabolite and a prodrug of arabinosylguanine (ara-G). This compound is a critical active pharmaceutical ingredient (API) with significant therapeutic value in oncology. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of targeted cancer treatments.

Application

• Oncological Pharmaceutical Manufacturing: As the active pharmaceutical ingredient (API) in the formulation of injectable chemotherapy drugs for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).
• Clinical Research & Development: Utilized in preclinical and clinical studies to investigate new treatment protocols, combination therapies, and mechanisms of action for T-cell malignancies.
• Reference Standard & Analytical Testing: Serves as a high-purity reference standard in quality control (QC) and analytical laboratories for method development, validation, and batch testing of commercial drug products.
• Biochemical Research: Used as a tool compound in biochemical assays to study nucleoside metabolism, DNA synthesis inhibition, and apoptosis in T-cells.

Basic Information

Product Name	Nelarabine
CAS No.	121032-29-9
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	2-Amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine; 506U78; GW506U78; Arranon® (brand name); Atriance® (brand name); Arabinosylguanine Prodrug; 9-β-D-Arabinofuranosyl-2-amino-6-methoxypurine
EINECS	Contact for details

Quality Control

Our Nelarabine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including but not limited to identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, purity, and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.