Description

2'-Deoxyadenosine-5'-o-(1-Thiodiphosphate), Rp-Isomer Sodium Salt is a high-purity, stereochemically defined nucleotide analog crucial for biochemical and pharmacological research. This compound serves as a valuable tool for studying enzyme mechanisms, particularly those involving ATP-dependent processes, due to its sulfur-for-oxygen substitution which confers resistance to hydrolysis. It is primarily utilized by research institutions and pharmaceutical companies engaged in enzymology, molecular biology, and drug discovery programs targeting nucleotide-binding proteins.

Application

• Enzymology Research: Used as a substrate analog to investigate the kinetics and mechanisms of kinases, ATPases, and other phosphotransferase enzymes.
• Molecular Biology: Employed in studies of DNA polymerases and other nucleic acid-metabolizing enzymes to understand fidelity and inhibition.
• Drug Discovery: Serves as a key intermediate or probe in screening assays and structure-activity relationship (SAR) studies for developing novel therapeutics.
• Biochemical Assay Development: Utilized in the creation of robust, non-hydrolyzable assay components for high-throughput screening (HTS) platforms.
• Structural Biology: Aids in X-ray crystallography and NMR studies to elucidate the three-dimensional structure of enzyme active sites with bound ligand.
• Signal Transduction Studies: Applied in research focused on purinergic signaling pathways and G-protein coupled receptor (GPCR) mechanisms.

Basic Information

Item	Detail
Product Name	2'-Deoxyadenosine-5'-o-(1-Thiodiphosphate), Rp-Isomer Sodium Salt
CAS No.	120496-69-7
Molecular Formula	C10H14N5O9P2S · xNa+
Molecular Weight	Contact for details
Synonyms	2'-Deoxyadenosine 5'-(α-thiodiphosphate), Rp-isomer; dADPαS (Rp); Adenosine-5'-[1-thiodiphosphate], 2'-deoxy-, Rp-isomer; Rp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium salt; Rp-dADPαS sodium salt; Rp-2'-dADPαS; Non-hydrolyzable dADP analog (Rp); ATPγS analog (deoxy, Rp)
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxyadenosine-5'-o-(1-Thiodiphosphate), Rp-Isomer Sodium Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity. Our quality assurance protocols are designed to meet the exacting standards of research and development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), chiral purity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity (Rp-Isomer)	≥ 98%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.