Description

Methylmalonyl-Methylalanyl-Arginyl-p-Nitroaniline CAS NO 119876-43-6 is a specialized synthetic peptide derivative designed for advanced biochemical research and development. This compound serves as a critical chromogenic substrate for the study and detection of specific protease enzymes, offering high sensitivity and selectivity in enzymatic assays. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic kit manufacturers focused on enzymology, drug discovery, and proteomics.

Application

• Protease Enzyme Substrate: Acts as a chromogenic substrate for the kinetic study and activity determination of specific serine or cysteine proteases.
• Biochemical Research: Used in academic and industrial R&D for investigating enzyme mechanisms, inhibition kinetics, and substrate specificity.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) assays to identify and characterize novel protease inhibitors as potential drug candidates.
• Diagnostic Development: Integral in the development of colorimetric diagnostic assays for detecting protease activity associated with certain diseases or biological pathways.
• Quality Control in Biomanufacturing: Used to monitor and validate the activity of protease enzymes produced for industrial or therapeutic applications.

Basic Information

Product Name	Methylmalonyl-Methylalanyl-Arginyl-p-Nitroaniline
CAS No.	119876-43-6
Molecular Formula	C23H34N8O8
Molecular Weight	550.57 g/mol
Synonyms	Methylmalonyl-Methylalanyl-Arginyl-4-Nitroanilide; Mma-Met-Ala-Arg-pNA; p-Nitroanilide Substrate; Protease Substrate 119876-43-6; Chromogenic Peptide Substrate; N-(4-Nitrophenyl)-L-argininamide derivative; L-Arginine, N2-[N-[3-[(2-methyl-1-oxopropoxy)amino]-1-oxobutyl]-L-alanyl]-, 4-nitroanilide
EINECS	Contact for details

Quality Control

Our Methylmalonyl-Methylalanyl-Arginyl-p-Nitroaniline is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.