Description

10-Methyl-11-Deazahomofolic Acid is a specialized folate analog and chemical intermediate of significant interest in pharmaceutical research and development. This compound is valued for its structural similarity to folic acid, making it a crucial building block for the synthesis of novel therapeutic agents and biochemical probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, metabolic disease research, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antifolate drugs and targeted cancer therapies.
• Biochemical Research: Used as a reference standard or inhibitor in studies of folate metabolism and enzyme kinetics (e.g., dihydrofolate reductase).
• Anticancer Agent Development: Serves as a core structure for developing compounds that interfere with nucleotide synthesis in rapidly dividing cells.
• Academic Research: Employed in universities and research labs for investigating cellular pathways and drug resistance mechanisms.
• Diagnostic Reagent Synthesis: Potential use in creating components for diagnostic assays targeting folate-dependent processes.

Basic Information

Product Name	10-Methyl-11-Deazahomofolic Acid
CAS No.	119770-55-7
Molecular Formula	C21H23N7O5
Molecular Weight	453.45 g/mol
Synonyms	10-Methyl-11-deazahomofolic acid; 11-Deaza-10-methylhomofolic acid; NSC 354646; 2-[[4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-6H-pyrimido[5,4-e][1,4]diazepin-10-yl)methylamino]benzoyl]amino]pentanedioic acid; 10-Methyl-5,8-dideazafolic acid homologue; LY-309887 analogue; Homofolate analogue
EINECS	Contact for details

Quality Control

Our 10-Methyl-11-Deazahomofolic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider conditions under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.