Description

2-Desamino-2-Methylaminopterin is a high-purity chemical intermediate and research compound, structurally related to classical antifolates. Its core value lies in its utility as a key building block for the synthesis of novel therapeutic agents and biochemical probes targeting folate-dependent pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology research, enzyme inhibition studies, and the development of targeted drug conjugates.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antifolate drugs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a tool compound in enzymatic studies, particularly for investigating dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Oncology R&D: Serves as a precursor for developing potential cancer therapeutics that interfere with DNA synthesis and cell proliferation.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Drug Discovery: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies to optimize drug candidates.

Basic Information

Product Name	2-Desamino-2-Methylaminopterin
CAS No.	118869-52-6
Molecular Formula	C₂₀H₂₂N₈O₅
Molecular Weight	454.44 g/mol
Synonyms	2-Desamino-2-methylaminopterin; 2-Methylaminopterin; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid; 2-Methyl-AP; 2-Methylaminopteroic acid glutamate; 2-Methylaminopteroylglutamate; NSC 757711
EINECS	Contact for details

Quality Control

Our 2-Desamino-2-Methylaminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.