Description

Disulfosuccinimidyl Tartrate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive disulfide group. This compound is essential for creating cleavable, reversible conjugates in protein chemistry and bioconjugation, enabling the study of protein interactions and the development of targeted drug delivery systems. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and diagnostic assay development.

Application

• Bioconjugation and Crosslinking: For creating reversible disulfide linkages between proteins, antibodies, peptides, and other biomolecules.
• Antibody-Drug Conjugate (ADC) Development: As a cleavable linker for attaching cytotoxic payloads to monoclonal antibodies, facilitating targeted cancer therapy.
• Protein Immobilization: For the reversible attachment of proteins to solid supports such as sensor chips, beads, or chromatography resins.
• Proteomics Research: In the study of protein-protein interactions and complex formation where reversible crosslinking is required.
• Diagnostic Reagent Manufacturing: In the production of enzyme-labeled antibodies or other detection conjugates for immunoassays.
• Polymer Modification: For introducing cleavable, functional groups into polymers or nanoparticles for controlled release applications.

Basic Information

Product Name	Disulfosuccinimidyl Tartrate
CAS No.	118674-04-7
Molecular Formula	C12H10N2O12S2
Molecular Weight	438.34 g/mol
Synonyms	DST; 3,3'-Dithiobis(succinimidyl tartrate); Disuccinimidyl tartrate disulfide; Succinimidyl tartrate disulfide; Tartaric acid bis(3-succinimidyl) disulfide; Bis(N-succinimidyl) tartrate disulfide; N,N'-Disuccinimidyl tartrate disulfide; 2,2'-[Dithiobis(2,1-ethanediyloxy-2-oxo-3,1-propanediyl)]bis[1,3-dioxo-2-isoindolineacetic acid]
EINECS	Contact for details

Quality Control

Our Disulfosuccinimidyl Tartrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, appearance, and moisture content.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.