Description

n-(12-((1-Pyrenesulfonyl)Amido)Dodecanoyl)Sphingosylphosphorylcholine is a sophisticated, fluorescently labeled sphingolipid derivative designed for advanced biochemical and biophysical research. This compound matters as a powerful molecular probe, enabling the study of lipid dynamics, membrane trafficking, and cellular signaling pathways with high sensitivity. It is primarily needed by researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focusing on lipidomics, cell biology, and the development of diagnostic assays.

Application

• Fluorescent Labeling of Sphingolipids: Acts as a critical tracer for visualizing the distribution and metabolism of sphingomyelin and related lipids in cellular membranes.
• Membrane Biophysics Research: Used to investigate lipid-lipid and lipid-protein interactions, membrane fluidity, and domain (lipid raft) formation using fluorescence spectroscopy and microscopy techniques.
• Cell Signaling Studies: Employed to track the intracellular fate and role of sphingosylphosphorylcholine derivatives in apoptosis, proliferation, and inflammatory signaling pathways.
• Model Membrane Systems: Incorporated into liposomes and supported lipid bilayers to create fluorescently tagged model systems for drug delivery and membrane interaction studies.
• High-Throughput Screening (HTS): Serves as a key reagent in developing fluorescence-based assays for screening compounds that modulate sphingolipid metabolism or related enzymes.
• Diagnostic Probe Development: Provides a foundation for creating sensitive probes for detecting specific enzymes or lipid metabolites in clinical research settings.

Basic Information

Product Name	n-(12-((1-Pyrenesulfonyl)Amido)Dodecanoyl)Sphingosylphosphorylcholine
CAS No.	118578-43-1
Molecular Formula	C56H86N3O9PS
Molecular Weight	1008.33 g/mol
Synonyms	Pyrene-labeled Sphingosylphosphorylcholine; N-(12-((1-Pyrenesulfonyl)amino)dodecanoyl)-sphingosylphosphocholine; Fluorescent Sphingomyelin Analog; Sphingosylphosphorylcholine, N-[12-[(1-pyrenesulfonyl)amino]dodecanoyl]-; Pyrene-SPC; Lyso-sphingomyelin pyrene derivative; 1-O-[N-(12-((1-Pyrenesulfonyl)amino)dodecanoyl)]-sphingosylphosphocholine
EINECS	Contact for details

Quality Control

Our n-(12-((1-Pyrenesulfonyl)Amido)Dodecanoyl)Sphingosylphosphorylcholine is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency required for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and fluorescence spectroscopy for performance validation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Fluorescence Properties	Excitation/Emission maxima typical for pyrene label
Solubility	Soluble in chloroform, DMSO, DMF; sparingly soluble in methanol
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.