Description

5,8,10-Trideaza-5,6,7,8-Tetrahydrofolate is a synthetic folate analog and a key intermediate in the research and development of novel chemotherapeutic agents. This compound is of significant interest for its role in the study of antifolate mechanisms and the inhibition of folate-dependent enzymes. It is primarily utilized by pharmaceutical R&D laboratories and academic institutions engaged in oncology research, metabolic pathway analysis, and the synthesis of targeted therapeutic molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of experimental antifolate drugs and targeted cancer therapies.
• Biochemical Research: Used as a tool compound to study folate metabolism, enzyme kinetics, and the mechanisms of dihydrofolate reductase (DHFR) inhibition.
• Oncology R&D: Serves as a precursor in the development of novel chemotherapeutic agents that interfere with nucleotide biosynthesis in rapidly dividing cells.
• Academic Research: Employed in university and institutional labs for fundamental studies in medicinal chemistry and molecular biology.
• Reference Standard: Can be used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	5,8,10-Trideaza-5,6,7,8-Tetrahydrofolate
CAS No.	118537-33-0
Molecular Formula	C17H19N5O4
Molecular Weight	357.37 g/mol
Synonyms	5,8,10-Trideazatetrahydrofolate; 5,8,10-Trideaza-5,6,7,8-tetrahydrofolic acid; TDTHF; NSC 127755; Antifolate Intermediate; Non-classical folate analog
EINECS	Contact for details

Quality Control

Our 5,8,10-Trideaza-5,6,7,8-Tetrahydrofolate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.