Description

Poly(n-Isopropylacrylamide-n-n-Butylacrylamide-n-Acryloxysuccinimide) is a functional, temperature-responsive copolymer that combines the thermosensitive properties of poly(N-isopropylacrylamide) with reactive succinimide ester groups. This unique structure makes it a critical material for creating smart, cross-linkable hydrogels and bio-conjugation platforms. It is essential for researchers and manufacturers in advanced biomaterials, drug delivery systems, and diagnostic assay development who require precise control over material properties and biofunctionalization.

Application

• Smart Hydrogel Fabrication: As a key component for creating temperature-responsive and chemically cross-linkable hydrogels for tissue engineering and controlled release.
• Bioconjugation & Protein Immobilization: Utilizing the reactive succinimide ester moiety for covalent attachment of proteins, antibodies, or peptides to surfaces and nanoparticles.
• Drug Delivery Carriers: Development of stimuli-responsive micelles or nanoparticles for targeted and controlled drug release applications.
• Diagnostic Assay Components: Functionalization of sensor surfaces and microfluidic devices to create bioactive interfaces.
• Cell Culture Substrates: Engineering surfaces with switchable properties for cell sheet harvesting and controlled cell adhesion studies.
• Chromatography Media: Modification of stationary phases to create affinity columns with tunable interaction properties.

Basic Information

Product Name	Poly(n-Isopropylacrylamide-n-n-Butylacrylamide-n-Acryloxysuccinimide)
CAS No.	118519-84-9
Molecular Formula	(C6H11NO)x(C7H13NO)y(C7H7NO4)z
Molecular Weight	Variable (Polymer)
Synonyms	PNIPAM-co-BAM-co-NAS; Poly(NIPAAm-co-BAAm-co-NAS); NIPAAm/BAAm/NAS Copolymer; Thermoresponsive NAS Copolymer; Reactive PNIPAM Copolymer; Poly(N-isopropylacrylamide-co-n-butylacrylamide-co-N-acryloxysuccinimide); PNIPAAm-BAAm-NAS Terpolymer; Smart Polymer with Active Ester
EINECS	Contact for details

Quality Control

Our Poly(n-Isopropylacrylamide-n-n-Butylacrylamide-n-Acryloxysuccinimide) is manufactured under controlled conditions to ensure batch-to-batch consistency. Each lot undergoes rigorous analysis, including determination of copolymer composition, molecular weight distribution, and active ester content. Certificates of Analysis (COA) detailing these specifications are available upon request to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the active ester groups and maintain reactivity. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (IR)	Conforms to structure
Composition Ratio (NIPAAm:BAAm:NAS)	As per customer grade (e.g., 70:20:10 mol%)
Number Average Molecular Weight (Mn)	5,000 - 50,000 Da (Typical)
Polydispersity Index (PDI)	≤ 1.5
Active Ester Content	≥ 95% of theoretical
Residual Monomer (HPLC)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, THF, acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.