Description

6-Thiodihydroorotate is a specialized sulfur-containing derivative of dihydroorotic acid, a key intermediate in pyrimidine biosynthesis. This compound is valued for its role as a biochemical research tool and a potential precursor in the synthesis of novel nucleoside analogs and enzyme inhibitors. It is primarily utilized by research institutions and pharmaceutical development companies engaged in metabolic pathway studies, anticancer agent discovery, and the development of antiviral compounds.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to the de novo pyrimidine biosynthesis pathway.
• Pharmaceutical Intermediates: Serves as a key building block for the synthesis of modified nucleosides and potential therapeutic agents.
• Metabolic Studies: Employed in cellular and molecular biology research to investigate nucleotide metabolism and its dysregulation in diseases.
• Antiviral & Anticancer Agent Development: Explored as a precursor for compounds targeting viral replication or rapidly dividing cancer cells.
• Enzyme Inhibition Assays: Acts as a reference compound for screening and characterizing dihydroorotate dehydrogenase (DHODH) inhibitors.
• Academic Research: Utilized in university and institutional labs for fundamental studies in bioorganic and medicinal chemistry.

Basic Information

Product Name	6-Thiodihydroorotate
CAS No.	118438-67-8
Molecular Formula	C5H6N2O4S
Molecular Weight	190.18 g/mol
Synonyms	6-Thiodihydroorotic acid; 6-Mercaptodihydroorotic acid; 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarbothioic acid; 6-SH-DHO; 6-Thio-DHO; 6-Thio-5,6-dihydroorotic acid; 6-Mercapto-5,6-dihydroorotic acid
EINECS	Contact for details

Quality Control

Our 6-Thiodihydroorotate is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.