Description

Lysobactin is a potent, naturally occurring cyclic depsipeptide antibiotic with a unique structure and mechanism of action. This compound is of significant interest for its activity against a range of Gram-positive bacteria, including multi-drug resistant strains. It is primarily utilized in advanced pharmaceutical research and development for novel antimicrobial agents, as well as in biochemical studies investigating bacterial cell wall synthesis.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of new antibiotic therapies.
• Antimicrobial Mechanism Studies: Used in biochemical and microbiological research to study the inhibition of bacterial cell wall biosynthesis.
• In-vitro Bioactivity Screening: Employed as a positive control in assays screening for antimicrobial activity against resistant pathogens like MRSA.
• Structure-Activity Relationship (SAR) Research: Provides a core scaffold for medicinal chemistry programs aimed at optimizing antibiotic potency and pharmacokinetics.

Basic Information

Product Name	Lysobactin
CAS No.	118374-47-3
Molecular Formula	C72H98N12O21
Molecular Weight	1443.6 g/mol
Synonyms	Katanosin B; LY 146032; Cilofungin; A21978C; L-687,781; Cyclic Depsipeptide Antibiotic A21978C; (3S,6R,9S,12R,15S,18S,21S,24R,30S,33S,36S,39S,42S,45S)-45-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-39-(3-aminopropyl)-30-(carboxymethyl)-6,9,18,21,24,33,36-heptaisobutyl-3,42-bis(1H-indol-3-ylmethyl)-1,4,7,10,13,16,19,22,25,28,31,34,37,40-tetradecaoxo-12,15-di(propan-2-yl)-1λ⁵,4λ⁵,7λ⁵,10λ⁵,13λ⁵,16λ⁵,19λ⁵,22λ⁵,25λ⁵,28λ⁵,31λ⁵,34λ⁵,37λ⁵,40λ⁵-tetradecazatetracyclo[40.4.0.0²⁴,⁵.0²⁴,⁵]hexatetracontane-1,4,7,10,13,16,19,22,25,28,31,34,37,40(46)-tetradecaol
EINECS	Contact for details

Quality Control

Our Lysobactin is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability for research purposes. All materials are accompanied by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.