Description

Aminopterin-α-Hyrazide is a specialized chemical derivative of the classic antifolate compound, aminopterin. This product is valued for its role as a key intermediate and research tool in the development of targeted therapeutic agents and biochemical probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, enzyme inhibition studies, and the synthesis of novel drug candidates.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis of novel antifolate drugs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a potent inhibitor of dihydrofolate reductase (DHFR) in enzymatic studies and pathway analysis.
• Oncology Studies: Employed in laboratory research to investigate mechanisms of cell proliferation and to develop new cancer treatment strategies.
• Chemical Synthesis: Acts as a versatile building block for the preparation of more complex molecules with potential biological activity.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Aminopterin-α-Hyrazide
CAS No.	118359-33-4
Molecular Formula	C19H20N8O4
Molecular Weight	424.42 g/mol
Synonyms	4-Amino-4-deoxypteroyl-α-hydrazide; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid α-hydrazide; Aminopterin α-hydrazide; α-Hydrazide of Aminopterin; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, α-hydrazide; Aminopterin hydrazide (α-isomer)
EINECS	Contact for details

Quality Control

Our Aminopterin-α-Hyrazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.