Description

4'-Methylangelicin-Thymine-4',5'-Photocycloadduct is a specialized photocycloaddition product derived from the reaction of 4'-methylangelicin and thymine under photochemical conditions. This compound is significant for its role as a key intermediate and model system in the study of DNA damage, photobiology, and the development of novel phototherapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in photochemistry, molecular biology, and the development of targeted light-activated therapies.

Application

• Photochemical Research: Serves as a critical model compound for studying DNA photolesions, specifically psoralen-thymine monoadducts and crosslinks.
• Photobiology Studies: Used to investigate the mechanisms of skin phototoxicity and the biological consequences of furocoumarin-DNA interactions.
• Pharmaceutical Intermediate: Acts as a key synthetic intermediate in the research and development of novel psoralen analogs for photodynamic therapy (PDT) and PUVA treatment.
• Analytical Reference Standard: Employed as a high-purity standard in analytical laboratories for method development and validation in the quantification of DNA adducts.
• Biochemical Tool: Utilized in enzymatic repair studies to understand the recognition and processing of specific DNA damage by repair proteins.
• Material Science Research: Investigated for potential applications in designing light-responsive biomaterials and molecular devices.

Basic Information

Item	Details
Product Name	4'-Methylangelicin-Thymine-4',5'-Photocycloadduct
CAS No.	118122-52-4
Molecular Formula	C20H18N2O6
Molecular Weight	382.37 g/mol
Synonyms	4'-Methylangelicin-thymine photocycloadduct; 4'5'-Cycloadduct of 4'-methylangelicin and thymine; 4'-Methylpsoralen-thymine adduct; 4'-Methylangelicin-thymine monoadduct; 4'-MeA-T photoadduct; 4'-Methyl-4,5',8-trimethylpsoralen-thymine cyclobutane adduct; 4'-Methylangelicin-thymine (4',5')-cycloadduct
EINECS	Contact for details

Quality Control

Our 4'-Methylangelicin-Thymine-4',5'-Photocycloadduct is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Each batch undergoes rigorous analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.