Description

Ethyl 1-Thio-β-D-Glucuronide is a specialized thioglycoside derivative of D-glucuronic acid, serving as a crucial biochemical tool and synthetic intermediate. Its core value lies in its role as a stable, activated glucuronide donor, enabling the study and synthesis of glucuronide conjugates relevant to drug metabolism and detoxification pathways. This compound is essential for researchers and manufacturers in pharmaceutical development, analytical chemistry, and biochemical research, particularly for investigating phase II metabolism and developing prodrugs.

Application

• Pharmaceutical Research & Development: Used as a key intermediate in the synthesis of glucuronide metabolites for pharmacokinetic and metabolic stability studies.
• Biochemical Probe Synthesis: Acts as a building block for creating labeled or modified glucuronides used as probes in enzyme assays (e.g., β-glucuronidase activity).
• Prodrug Design: Employed in the development of prodrugs where glucuronidation is a targeted release mechanism, leveraging its activated thioethyl group.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for calibrating equipment and validating methods in LC-MS/MS or HPLC analysis of glucuronide conjugates.
• Enzymology Studies: Utilized as a substrate or inhibitor in studies of UDP-glucuronosyltransferase (UGT) enzymes to understand isoform specificity and kinetics.
• Chemical Synthesis: Functions as a versatile glycosyl donor in organic synthesis for constructing complex carbohydrate molecules or glycoconjugates.

Basic Information

Product Name	Ethyl 1-Thio-β-D-Glucuronide
CAS No.	117757-06-9
Molecular Formula	C8H14O7S
Molecular Weight	254.26 g/mol
Synonyms	Ethyl 1-Thio-β-D-Glucopyranosiduronic Acid; 1-Thioethyl β-D-Glucuronide; S-Ethyl 1-Thio-β-D-glucopyranosiduronic Acid; β-D-Glucopyranosiduronic Acid, 1-thioethyl-; Ethyl β-D-Thioglucuronide; 1-S-Ethyl-1-thio-β-D-glucuronic Acid; ETG (context-specific)
EINECS	Contact for details

Quality Control

Our Ethyl 1-Thio-β-D-Glucuronide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for research and development applications. Comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), identity (by IR, NMR), and impurity profiles are provided to guarantee reliable and reproducible results in your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider keeping the container under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.