Description

n-Succinyl-Phe-Gly-Leu β-Naphthylamide is a specialized synthetic peptide substrate designed for enzymatic activity studies. This compound is of significant value in biochemical and pharmaceutical research for its role as a chromogenic or fluorogenic substrate for specific proteolytic enzymes, particularly cathepsins and other peptidases. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in enzyme kinetics, inhibitor screening, and protease assay development.

Application

• Enzyme Assay Substrate: Used as a chromogenic/fluorogenic substrate for the detection and quantification of protease activity, including cathepsin B, H, and L.
• Biochemical Research: Essential tool for studying enzyme kinetics, inhibition mechanisms, and substrate specificity in academic and industrial R&D laboratories.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) assays to identify and characterize novel protease inhibitors as potential therapeutic agents.
• Diagnostic Development: Serves as a key component in developing diagnostic assays for diseases involving abnormal protease activity.
• Cell Biology Studies: Used to investigate intracellular proteolytic processes and protease functions in various cellular pathways.

Basic Information

Product Name	n-Succinyl-Phe-Gly-Leu β-Naphthylamide
CAS No.	117756-24-8
Molecular Formula	C31H36N4O6
Molecular Weight	560.64 g/mol
Synonyms	Succinyl-Phenylalanylglycyl-Leucine 2-Naphthylamide; Suc-Phe-Gly-Leu-βNA; Suc-F-G-L-2NA; Cathepsin B Substrate; N-Succinyl-L-phenylalanyl-L-glycyl-L-leucine 4-methyl-7-coumarylamide (related fluorogenic analog); Protease Substrate 117756-24-8; N-Suc-Phe-Gly-Leu-2-Naphtylamide
EINECS	Contact for details

Quality Control

Our n-Succinyl-Phe-Gly-Leu β-Naphthylamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) providing specifications for assay, related substances, and other critical parameters is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.