Description

Chromium (III) Bidentate Guanosine 5'-(Beta,γ-Imido)Triphosphate is a specialized, non-hydrolyzable nucleotide analog complexed with trivalent chromium. This compound is engineered to serve as a potent and stable inhibitor of GTP-dependent enzymes, making it a critical tool for mechanistic biochemical studies. It is primarily utilized by researchers and developers in pharmaceutical discovery, enzymology, and molecular biology to investigate signal transduction pathways and protein function without the interference of hydrolysis.

Application

• Enzymology Research: Acts as a stable GTP analog to inhibit G-proteins, GTPases, and other nucleotide-binding enzymes in kinetic and structural studies.
• Signal Transduction Studies: Used to probe and modulate cellular signaling pathways that rely on GTP binding and hydrolysis.
• Pharmaceutical Screening: Serves as a key reagent in high-throughput assays to identify potential therapeutic compounds that target GTPase activity.
• Biochemical Assay Development: Provides a non-hydrolyzable control in assays measuring enzyme activity, ATP/GTP consumption, or phosphate release.
• Structural Biology: Aids in X-ray crystallography and NMR studies by providing a hydrolysis-resistant ligand to stabilize protein-nucleotide complexes.
• Metabolic Pathway Analysis: Used to study the role of GTP in metabolic regulation and biosynthesis.

Basic Information

Product Name	Chromium (III) Bidentate Guanosine 5'-(Beta,γ-Imido)Triphosphate
CAS No.	117604-44-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cr(III)-Guanosine 5'-[β,γ-imido]triphosphate; Chromium(III)-GMP-PNP complex; Cr(III)-GMPPNP; Guanosine 5'-(β,γ-imido)triphosphate chromium (III) salt; Non-hydrolyzable GTP analog chromium complex; GMP-PNP-Cr(III); Chromium (3+) bidentate GMP-PNP
EINECS	Contact for details

Quality Control

Our Chromium (III) Bidentate Guanosine 5'-(Beta,γ-Imido)Triphosphate is produced under stringent conditions to ensure batch-to-batch consistency and high chemical purity for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification. Certificates of Analysis (COA) detailing purity, identity, and stability are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Chromium Content	Confirm by ICP-MS or AAS
Water Content (KF)	≤ 2.0%
Solubility	Soluble in aqueous buffer, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.