Description

Adenosine 3',5'-Cyclic Methylphosphonate CAS NO 117571-83-2 is a chemically modified analog of cyclic adenosine monophosphate (cAMP), where a methylphosphonate group replaces the standard phosphate. This structural modification enhances its stability against enzymatic hydrolysis, making it a valuable non-hydrolyzable tool compound for biochemical research. It is primarily used by researchers and developers in the life sciences sector to study cAMP-dependent signaling pathways, enzyme mechanisms, and cellular regulation without interference from phosphodiesterase activity.

Application

• Biochemical Research: Serves as a stable, cell-permeable analog of cAMP for investigating protein kinase A (PKA) activation and other cAMP-mediated signal transduction processes.
• Enzyme Inhibition Studies: Used as a competitive inhibitor or substrate analog to study the kinetics and specificity of phosphodiesterases and other nucleotide-binding enzymes.
• Pharmaceutical Development: Employed in early-stage drug discovery as a reference compound for screening and validating new therapeutics targeting cAMP pathways.
• Cell Biology: Applied in cell culture experiments to modulate intracellular cAMP levels and observe downstream effects on gene expression, metabolism, and cell proliferation.
• Diagnostic Reagent Manufacturing: Utilized as a key component in the formulation of assay kits and diagnostic reagents for research and clinical testing.

Basic Information

Product Name	Adenosine 3',5'-Cyclic Methylphosphonate
CAS No.	117571-83-2
Molecular Formula	C11H14N5O6P
Molecular Weight	343.23 g/mol
Synonyms	cAMP Methylphosphonate; Adenosine 3',5'-cyclic methylphosphorothioate (common misnomer); 8-(Methylphosphono)-cyclic adenosine monophosphate; Cyclic AMP methylphosphonate analog; 3',5'-cAMPS methylphosphonate; Sp-cAMPS methylphosphonate; Rp-cAMPS methylphosphonate; Non-hydrolyzable cAMP analog
EINECS	Contact for details

Quality Control

Every batch of Adenosine 3',5'-Cyclic Methylphosphonate is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.