Description

Theophylline-D6 is a stable isotope-labeled analog of theophylline, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative analytical methods, ensuring accuracy and reliability in research and quality control. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Used as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the precise quantification of theophylline.
• Critical for pharmacokinetic and bioequivalence studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• Enables accurate analysis in therapeutic drug monitoring (TDM) applications for patient samples.
• Supports metabolite identification and profiling in drug metabolism and pharmacodynamics (DMPK) research.
• Facilitates method development and validation in regulatory-compliant analytical laboratories (FDA, EMA).
• Employed in clinical research for robust and reproducible data generation.
• Used in forensic and toxicological analysis for the definitive identification of theophylline.

Basic Information

Product Name	Theophylline-D6
CAS No.	117490-39-8
Molecular Formula	C7H2D6N4O2
Molecular Weight	186.22 g/mol
Synonyms	1,3-Dimethyl-2,6-dioxo-7H-purine-7-d6; 1,3-Dimethylxanthine-d6; Theophylline (hexadeuterated); Theophylline-d6; [2H6]-Theophylline; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione-d6; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, d6-
EINECS	Contact for details

Quality Control

Every batch of Theophylline-D6 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for sensitive mass spectrometry applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and absence of interfering impurities. Our quality commitment supports compliance in GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.