Description

Phenylpropionyl-Coenzyme A is a specialized biochemical intermediate, a coenzyme A thioester derivative of phenylpropionic acid. This compound is essential for researchers studying metabolic pathways, particularly those involving fatty acid β-oxidation and the catabolism of aromatic compounds in microbial and mammalian systems. It serves as a critical substrate or reference standard in enzymology, metabolic engineering, and pharmaceutical research for developing targeted therapies.

Application

• Enzymology Research: Used as a specific substrate to study the activity and kinetics of acyl-CoA synthetases, dehydrogenases, and other enzymes involved in phenylpropionate metabolism.
• Metabolic Pathway Analysis: A key intermediate for investigating the β-oxidation pathway of phenylpropionic acid and related aromatic fatty acids in vitro.
• Biochemical Reference Standard: Serves as a high-purity analytical standard for the identification and quantification of acyl-CoA esters in complex biological samples via LC-MS or HPLC.
• Pharmaceutical Development: Employed in research targeting metabolic disorders or for probing enzyme inhibitors relevant to diseases linked to CoA-dependent metabolism.
• Microbial Metabolism Studies: Utilized to elucidate bacterial degradation pathways of aromatic compounds, relevant to environmental bioremediation and industrial biotechnology.
• Diagnostic Reagent Manufacturing: Can be incorporated into enzymatic assay kits for clinical or research diagnostics that measure specific metabolic functions.

Basic Information

Product Name	Phenylpropionyl-Coenzyme A
CAS No.	117411-09-3
Molecular Formula	C₃₀H₄₈N₇O₁₇P₃S
Molecular Weight	927.77 g/mol
Synonyms	3-Phenylpropionyl-CoA; 3-Phenylpropionyl-Coenzyme A; Phenylpropionyl-CoA; Hydrocinnamoyl-Coenzyme A; Hydrocinnamoyl-CoA; Coenzyme A, S-(3-phenylpropanoate); S-(3-Phenylpropanoyl)coenzyme A; (3-Phenylpropanoyl)CoA
EINECS	Contact for details

Quality Control

Our Phenylpropionyl-Coenzyme A is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and specific tests for identity and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term stability, it is recommended to store under an inert atmosphere and avoid repeated freeze-thaw cycles. Keep containers sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
UV-Vis Spectrum	Characteristic for Acyl-CoA esters
Water Content (KF)	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.