Description

6-(n-Trifluoroacetyl)Aminocaproic Acid n-Succinimidyl Ester is a highly reactive, heterobifunctional crosslinking agent designed for the site-specific conjugation of biomolecules. Its core value lies in enabling the stable attachment of labels, probes, or other functional groups to proteins, peptides, and other amine-containing compounds under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay production, where precise and reliable bioconjugation is critical.

Application

• Bioconjugation and Protein Labeling: Primary application for attaching fluorophores, biotin, or other tags to antibodies, enzymes, and peptides for research and diagnostics.
• Proteomics Research: Used in cross-linking mass spectrometry (XL-MS) studies to investigate protein-protein interactions and structural biology.
• Immunoassay Development: Key reagent for preparing enzyme-antibody or hapten-protein conjugates used in ELISA and other immunoassays.
• Drug Delivery Systems: Facilitates the covalent linkage of targeting ligands or therapeutic payloads to carrier molecules like polymers or nanoparticles.
• Surface Functionalization: Employed to modify sensor chips, microarrays, and other solid supports with amine-reactive surfaces for biomolecule immobilization.
• Peptide Synthesis: Acts as an activated ester intermediate in the synthesis of complex, modified peptides for therapeutic and research applications.

Basic Information

Product Name	6-(n-Trifluoroacetyl)Aminocaproic Acid n-Succinimidyl Ester
CAS No.	117032-51-6
Molecular Formula	C13H15F3N2O5
Molecular Weight	336.27 g/mol
Synonyms	6-(Trifluoroacetamido)hexanoic Acid N-Hydroxysuccinimide Ester; 6-(Trifluoroacetylamino)caproic Acid N-Succinimidyl Ester; 6-(N-Trifluoroacetyl)aminocaproyloxysuccinimide; N-Succinimidyl 6-(Trifluoroacetamido)hexanoate; N-6-(Trifluoroacetyl)aminocaproyloxysuccinimide; TFACA-OSu; Trifluoroacetyl-6-aminocaproic Acid NHS Ester; NHS Ester of 6-(Trifluoroacetamido)hexanoic Acid
EINECS	Contact for details

Quality Control

Our 6-(n-Trifluoroacetyl)Aminocaproic Acid n-Succinimidyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and functional activity testing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications. We support GMP-grade production for critical pharmaceutical and diagnostic applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.