Description

Mtx-Ala CAS NO 116819-28-4 is a specialized chemical compound, a methotrexate derivative, designed for advanced research and development applications. This high-purity intermediate is critical for scientists working on targeted drug delivery systems and novel therapeutic conjugates. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic research institutions focused on oncology and autoimmune disease treatment strategies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced antibody-drug conjugates (ADCs) and targeted cancer therapies.
• Bioconjugation Research: Used to attach methotrexate analogs to antibodies, peptides, or other targeting molecules for enhanced cellular uptake.
• Prodrug Development: Serves as a precursor in the design of prodrugs that require specific enzymatic activation at the disease site.
• Biochemical Tool Compound: Employed in laboratory studies to investigate folate metabolism inhibition and its effects on cellular proliferation.
• Linker Chemistry: Functions as a specialized spacer or linker molecule in the construction of complex bioactive molecules.
• Preclinical Studies: Essential for in vitro and in vivo research models evaluating the efficacy and pharmacokinetics of new therapeutic entities.

Basic Information

Product Name	Mtx-Ala
CAS No.	116819-28-4
Molecular Formula	C23H27N9O5
Molecular Weight	509.52 g/mol
Synonyms	L-2-Amino-3-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)propanoic acid; Methotrexate-Alanine; MTX-Ala; MTX-α-Alanine; N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-alanine; Alanine Methotrexate Conjugate; 4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid (2-amino-1-carboxyethyl)amide
EINECS	Contact for details

Quality Control

Our Mtx-Ala is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.