Description

4-Aminobiphenyl -D-Glucuronide Sodium Salt is a high-purity biochemical conjugate, specifically the sodium salt of the glucuronic acid derivative of 4-aminobiphenyl. This compound is a critical reference standard and metabolite in advanced toxicological and pharmacological research, enabling precise analytical quantification. It is primarily utilized by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in metabolism studies, biomarker validation, and method development for detecting aromatic amine exposures.

Application

• Analytical Reference Standard: Primary use as a certified standard for HPLC, LC-MS, and GC-MS analysis in bioanalytical laboratories.
• Metabolite Research: Study of Phase II metabolism, specifically glucuronidation pathways, of aromatic amines like 4-aminobiphenyl.
• Biomarker Development: Calibration and validation in assays designed to detect and quantify specific DNA adducts or metabolite levels in biological samples for exposure assessment.
• Toxicology & Carcinogenicity Studies: Investigation of the metabolic fate, activation, and detoxification pathways of known carcinogenic amines.
• Pharmaceutical R&D: Use in drug metabolism and pharmacokinetics (DMPK) studies for compounds metabolized via similar conjugation pathways.
• Diagnostic Kit Manufacturing: A key component in the development and quality control of diagnostic kits for occupational or environmental monitoring.

Basic Information

Product Name	4-Aminobiphenyl -D-Glucuronide Sodium Salt
CAS No.	116490-30-3
Molecular Formula	C18H19NNaO7
Molecular Weight	384.34 g/mol
Synonyms	4-Aminobiphenyl Glucuronide Sodium Salt; N-Phenyl-4-aminobiphenyl Glucuronide Sodium Salt; 4-ABP-Gluc Sodium Salt; 4-Aminodiphenyl Glucuronide Sodium Salt; 4-Biphenylamine Glucuronide Sodium Salt; [1-(4-Biphenylyl)-β-D-glucopyranosiduronic acid] Sodium Salt; Xenobiotic Metabolite Sodium Salt; Aromatic Amine Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of 4-Aminobiphenyl -D-Glucuronide Sodium Salt is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stability, meeting the stringent requirements for research-grade biochemicals. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity (by HPLC), identity confirmation (NMR, MS), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.