Description

8-(2-[7-Nitro-4-Benzofurazanyl]Aminoethylthio]Guanosine-3',5'-Cyclic Monophosphate Sodium Salt is a high-purity, chemically modified cyclic nucleotide analog designed for advanced biochemical research. This compound serves as a critical tool molecule, primarily functioning as a potent and cell-permeable activator of cyclic GMP-dependent protein kinase (PKG). It is essential for researchers and pharmaceutical developers in neuroscience, cardiovascular biology, and signal transduction studies, where precise modulation of intracellular cGMP pathways is required.

Application

• Biochemical Research: A key reagent for studying the role of cGMP and PKG in cellular signaling cascades.
• Neuroscience Studies: Used to investigate synaptic plasticity, neuronal excitability, and neuroprotection mechanisms.
• Cardiovascular Research: Applied in studies of vasodilation, smooth muscle relaxation, and platelet function.
• Drug Discovery & Screening: Serves as a reference standard and positive control in high-throughput assays targeting the cGMP/PKG pathway.
• Cell Biology: Utilized to probe intracellular second messenger systems and their downstream effects on gene expression and cell function.
• Academic & Pharmaceutical R&D: Fundamental for basic research and the development of novel therapeutics for conditions like hypertension, erectile dysfunction, and neurodegenerative diseases.

Basic Information

Product Name	8-(2-[7-Nitro-4-Benzofurazanyl]Aminoethylthio]Guanosine-3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	115993-88-9
Molecular Formula	C₂₂H₂₁N₈O₉PSNa
Molecular Weight	627.48 g/mol
Synonyms	8-(2-[7-Nitro-4-benzofurazanyl]aminoethylthio)guanosine-3',5'-cyclic monophosphate sodium salt; 8-pCPT-cGMP sodium salt; 8-(4-Chlorophenylthio)guanosine-3',5'-cyclic monophosphate sodium salt (common name); PKG activator; cGMP analog; B0084 (potential catalog number); 8-(2-((7-Nitro-4-benzofurazanyl)amino)ethylthio)guanosine-3',5'-cyclic monophosphate sodium salt
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical is governed by strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and endotoxin levels where applicable. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.