Description

8-(2-Aminoethylthio) Guanosine-3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic GMP (cGMP) designed for advanced biochemical and pharmacological research. This compound is a critical tool for studying intracellular signaling pathways, particularly those mediated by cGMP-dependent protein kinases (PKG) and cyclic nucleotide-gated ion channels. It is essential for researchers and developers in the fields of neurobiology, cardiovascular research, and drug discovery, where precise modulation of secondary messenger systems is required.

Application

• Biochemical Research: As a potent and membrane-permeable activator of PKG for studying smooth muscle relaxation, platelet aggregation, and neuronal signal transduction.
• Pharmaceutical Development: Used as a reference standard and pharmacological probe in high-throughput screening for novel therapeutics targeting cGMP pathways.
• Cell Signaling Studies: Investigation of nitric oxide (NO) and natriuretic peptide signaling cascades in cardiovascular and metabolic disease models.
• Neuroscience: Research into synaptic plasticity, long-term potentiation (LTP), and memory formation mechanisms.
• Enzyme Assays: Substrate or activator for in vitro assays of phosphodiesterases (PDEs) and other cGMP-metabolizing enzymes.
• Academic & Institutional Research: A key reagent for graduate and post-doctoral studies in molecular biology and physiology.

Basic Information

Product Name	8-(2-Aminoethylthio) Guanosine-3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	115974-70-4
Molecular Formula	C12H15N6O7PS2Na
Molecular Weight	488.37 g/mol
Synonyms	8-(2-Aminoethylthio)-cGMP sodium salt; 8-AET-cGMP Na; 8-(2-Aminoethylthio)guanosine 3',5'-cyclic monophosphate sodium salt; cGMP, 8-(2-aminoethylthio)-, sodium salt; 8-Thioethylamino-cGMP; Sodium 8-(2-aminoethylthio)guanosine 3',5'-cyclic phosphate; Membrane-permeable cGMP analog
EINECS	Contact for details

Quality Control

Our 8-(2-Aminoethylthio) Guanosine-3',5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and potency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.