Description

[1-(2-Nitrophenyl)-Ethyl]-Guanosine-5''-Diphosphoric Acid Disodium Salt is a specialized nucleotide derivative, a key intermediate in the synthesis of modified nucleosides and nucleotides for advanced biochemical research. Its core value lies in enabling the study of enzyme mechanisms, nucleic acid metabolism, and the development of novel diagnostic probes and therapeutic agents. This high-purity biochemical is essential for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on molecular biology and medicinal chemistry.

Application

• Enzyme Substrate & Inhibitor Studies: Used as a substrate analog to investigate the kinetics and mechanisms of kinases, polymerases, and other nucleotide-processing enzymes.
• Biochemical Probe Synthesis: Serves as a critical building block for creating fluorescently labeled or otherwise modified nucleotide probes for detection and imaging applications.
• Medicinal Chemistry Research: Employed in the design and synthesis of novel nucleoside-based drug candidates targeting viral infections and cancers.
• Metabolic Pathway Analysis: Acts as a tracer or inhibitor to study purine and pyrimidine salvage pathways within cellular systems.
• Diagnostic Assay Development: Utilized in the formulation of high-sensitivity assays for enzyme activity detection and biomarker research.

Basic Information

Product Name	[1-(2-Nitrophenyl)-Ethyl]-Guanosine-5''-Diphosphoric Acid Disodium Salt
CAS No.	115850-14-1
Molecular Formula	C18H20N6Na2O13P2
Molecular Weight	660.30 g/mol
Synonyms	1-(2-Nitrophenyl)ethyl-GDP disodium salt; 2'-Deoxy-2'-(2-nitrophenyl)guanosine-5'-diphosphate disodium; NPE-caged GDP disodium salt; Guanosine 5'-[β,γ-(1-(2-nitrophenyl)ethyl)]diphosphate disodium salt; Caged GDP, 2-Nitrophenylethyl (NPE) protected; 1-(2-Nitrophenyl)ethyl ester of GDP disodium salt; Photolabile GDP derivative
EINECS	Contact for details

Quality Control

Our production of [1-(2-Nitrophenyl)-Ethyl]-Guanosine-5''-Diphosphoric Acid Disodium Salt adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity, typically exceeding 95% (HPLC). Each lot is characterized by NMR (1H, 31P) and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, desiccate under inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.