Description

20-Aldehyde Leukotriene B4 is a specialized leukotriene analog and a key synthetic intermediate in advanced biochemical research. This compound is crucial for studying the inflammatory pathways mediated by leukotriene B4, particularly in the context of receptor binding and metabolic fate. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on immunology, inflammation, and respiratory disease models. The high-purity material enables precise mechanistic studies and the development of novel therapeutic agents.

Application

• Biochemical Research: Serves as a critical reference standard and synthetic precursor in leukotriene metabolism and signaling pathway studies.
• Pharmaceutical Development: Used as an intermediate in the synthesis of novel anti-inflammatory drug candidates and leukotriene receptor antagonists.
• Immunology Studies: Applied in in vitro and in vivo models to investigate neutrophil chemotaxis and other inflammatory responses.
• Analytical Standard: Employed in HPLC, LC-MS, and other analytical methods for the quantification and identification of leukotriene metabolites.
• Enzyme Substrate: Used to study the activity and inhibition of key enzymes like leukotriene A4 hydrolase.

Basic Information

Product Name	20-Aldehyde Leukotriene B4
CAS No.	115609-68-2
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	20-Oxo-leukotriene B4; 20-Formyl-LTB4; 5(S),12(R)-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic-20-al; 20-Aldehyde-5(S),12(R)-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; LTB4-20-al; 20-CHO-LTB4; 20-Carbaldehyde Leukotriene B4
EINECS	Contact for details

Quality Control

Our 20-Aldehyde Leukotriene B4 is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The material is hygroscopic and should be handled in a dry environment to prevent moisture uptake. Allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.