Description

L-A-Phosphatidic Acid Monomethyl Ester is a high-purity, synthetic phospholipid derivative that serves as a critical intermediate and functional ingredient in advanced biochemical research and formulation. This compound is valued for its role in modulating membrane properties and cellular signaling pathways. It is essential for researchers and manufacturers in the pharmaceutical, cosmetic, and nutraceutical industries developing liposomal drug delivery systems, bioactive formulations, and model membrane studies.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: A key phospholipid component for constructing stable, tunable drug delivery vesicles for mRNA, siRNA, and small molecule therapeutics.
• Biochemical Research: Used as a substrate or standard in enzymatic assays and studies of lipid metabolism, signal transduction, and phospholipase activity.
• Cosmetic Actives: Incorporated into high-performance skincare products for its potential skin barrier repair and moisturizing properties.
• Nutraceutical Encapsulation: Employed in the microencapsulation of sensitive bioactive ingredients to enhance stability and bioavailability.
• Model Membrane Systems: Used to create defined lipid bilayers for biophysical studies and membrane protein research.
• Cell Culture Media Supplement: Serves as a lipid source in specialized serum-free media formulations.

Basic Information

Product Name	L-A-Phosphatidic Acid Monomethyl Ester
CAS No.	115459-66-0
Molecular Formula	C40H77O8P (Typical for 1,2-dipalmitoyl derivative)
Molecular Weight	717.00 g/mol (approx.)
Synonyms	1,2-Dipalmitoyl-sn-glycero-3-phosphate monomethyl ester; Phosphatidic acid methyl ester; PA-ME; L-α-Phosphatidic acid monomethyl ester; 1,2-Dihexadecanoyl-sn-glycerol-3-phosphate methyl ester; sn-Glycero-3-phosphoric acid monomethyl ester, 1,2-dipalmitoyl; Methyl phosphatidate; DPPA-ME
EINECS	Contact for details

Quality Control

Our L-A-Phosphatidic Acid Monomethyl Ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, impurity profile, and fatty acid composition. Our quality commitment supports applications requiring high-purity standards for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (TLC)	Single major spot
Solubility	Soluble in chloroform, methanol, ethanol; insoluble in water
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.