Description

N N'-Bis(3-Maleimidopropionyl)-2-Hydroxy-1,3-propanediamine is a specialized heterobifunctional crosslinking agent featuring both maleimide and amine-reactive groups. This compound is engineered for the precise conjugation of biomolecules, enabling the creation of stable, site-specific linkages critical for advanced research and diagnostics. It is essential for scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and the production of diagnostic reagents and therapeutic proteins.

Application

• Bioconjugation Reagent: For the covalent coupling of peptides, proteins, and antibodies to other molecules, surfaces, or carriers.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a key chemical bridge connecting cytotoxic payloads to monoclonal antibodies in targeted cancer therapies.
• Diagnostic Assay Development: Used to immobilize capture antibodies or antigens on solid supports for ELISA, lateral flow assays, and biosensors.
• Polymer Modification: Functionalizes polymers and hydrogels with reactive maleimide groups for creating smart biomaterials and drug delivery systems.
• Protein Labeling and Tagging: Enables the site-specific attachment of fluorescent dyes, affinity tags, or other probes to proteins for tracking and purification.
• Research Tool: A critical reagent in academic and industrial R&D for studying protein-protein interactions and developing novel biotherapeutics.

Basic Information

Product Name	N N'-Bis(3-Maleimidopropionyl)-2-Hydroxy-1,3-propanediamine
CAS No.	115388-98-2
Molecular Formula	C17H20N4O7
Molecular Weight	392.37 g/mol
Synonyms	1,3-Bis(3-maleimidopropionamido)-2-propanol; BM(PEO)3 (common abbreviation); 2-Hydroxy-1,3-propanediamine, N,N'-bis(3-maleimidopropionyl)-; Heterobifunctional PEO crosslinker; Maleimide-PEO-amine crosslinker; BM(PEO)3 Crosslinker; N,N'-Bis[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)propanoyl]-2-hydroxy-1,3-propanediamine
EINECS	Contact for details

Quality Control

Our N N'-Bis(3-Maleimidopropionyl)-2-Hydroxy-1,3-propanediamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.