Description

H-Pro-Amc Hbr CAS NO 115388-93-7 is a protected amino acid derivative, specifically the hydrobromide salt of Fmoc-L-proline amide. This compound is a critical building block in solid-phase peptide synthesis (SPPS), valued for its role in introducing proline residues with high coupling efficiency and minimal racemization. It is essential for research and production teams in pharmaceutical development, biotechnology, and academic research focused on creating novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the stepwise construction of peptide chains on resin, particularly for incorporating proline.
• Pharmaceutical Intermediates: Serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) for peptide drugs targeting metabolic, oncological, and neurological disorders.
• Bioconjugation & Probe Development: Used to create labeled peptides for imaging, diagnostic assays, and studying protein-protein interactions.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Institutional Research: A staple chemical for research into peptide structure, function, and bioactivity in university and government laboratories.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for GMP and non-GMP peptide production.

Basic Information

Product Name	H-Pro-Amc Hbr
CAS No.	115388-93-7
Molecular Formula	C₂₀H₂₀N₂O₃·HBr
Molecular Weight	417.30 g/mol
Synonyms	Fmoc-L-Proline amide hydrobromide; Fmoc-Pro-NH₂·HBr; N-(9-Fluorenylmethoxycarbonyl)-L-prolinamide hydrobromide; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-pyrrolidinecarboxamide hydrobromide; Fmoc-Pro-Amide·HBr; Fmoc-Pro-NH2 HBr; Nα-Fmoc-L-prolinamide HBr; Fmoc-Pro-Am HBr
EINECS	Contact for details

Quality Control

Every batch of H-Pro-Amc Hbr is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive peptide synthesis. A Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and identity is supplied with each shipment. Our quality protocols are designed to support research and production needs under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.