Description

(+/-)-2-Methoxy-3,8-dioxocephalotax-1-ene is a complex, semi-synthetic cephalotaxine derivative, a key structural motif in the homoharringtonine family of natural products. This compound serves as a critical advanced intermediate for the synthesis of novel anti-cancer agents and for pharmacological research. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: A pivotal building block for the synthesis of cephalotaxus esters and analogs with potential anti-leukemic activity.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of protein synthesis inhibition and apoptosis induction.
• Lead Compound Optimization: Serves as a core scaffold for medicinal chemistry programs aimed at developing new chemotherapeutic agents.
• Reference Standard: Employed as an analytical standard in quality control and metabolic studies for related drug candidates.
• Academic Synthesis: A valuable compound for teaching and research in advanced organic synthesis and natural product chemistry.

Basic Information

Product Name	(+/-)-2-Methoxy-3,8-dioxocephalotax-1-ene
CAS No.	114942-83-5
Molecular Formula	C19H21NO5
Molecular Weight	343.38 g/mol
Synonyms	2-Methoxy-3,8-dioxocephalotax-1-ene; Cephalotaxine-2-methoxy-3,8-dione derivative; (±)-2-Methoxy-3,8-dioxocephalotax-1-ene; 1-Cephalotaxene, 2-methoxy-3,8-dioxo-; Harringtonine precursor intermediate; Cephalotaxus alkaloid intermediate; DL-2-Methoxy-3,8-dioxocephalotax-1-ene
EINECS	Contact for details

Quality Control

Our (+/-)-2-Methoxy-3,8-dioxocephalotax-1-ene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.