Description

(2R)-4α-(Dimethylamino)-3,4,5,6,11,12,13,14-Octahydro-3β,5β,8,10,13β-Pentahydroxy-11α-Methoxy-6,13-Dimethyl-2α,6α-Epoxy-2H-Naphthaceno[1,2-B]Oxocin-9,16-Dione is a complex, high-purity pharmaceutical intermediate with a defined stereochemistry. This compound is critical for ensuring the efficacy and safety profile of final active pharmaceutical ingredients (APIs) in advanced therapeutic applications. It is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development and production of novel antibiotic and anticancer agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathway for novel tetracycline-class antibiotics.
• Anticancer Drug Research: Serves as a precursor in the development of targeted cancer therapies due to its complex naphthacene core structure.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological and mechanism-of-action studies.
• API Synthesis: Essential for the GMP-compliant manufacturing of final active pharmaceutical ingredients requiring high stereochemical purity.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for complex molecules in pilot plants.

Basic Information

Product Name	(2R)-4α-(Dimethylamino)-3,4,5,6,11,12,13,14-Octahydro-3β,5β,8,10,13β-Pentahydroxy-11α-Methoxy-6,13-Dimethyl-2α,6α-Epoxy-2H-Naphthaceno[1,2-B]Oxocin-9,16-Dione
CAS No.	114926-58-8
Molecular Formula	C₂₈H₃₇NO₁₀
Molecular Weight	547.60 g/mol
Synonyms	9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A; (2R,3S,4R,5R,8R,10R,11R,12S,13S)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10,13-tetrahydroxy-3,5,8,10,12,13-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one; TEA 0777; Azaerythromycin A; 9a-Methyl-9a-aza-9-deoxo-9a-homoerythromycin A; 9a-Aza-9a-methyl-9-deoxo-9a-homoerythromycin A
EINECS	Contact for details

Quality Control

Our (2R)-4α-(Dimethylamino)-3,4,5,6,11,12,13,14-Octahydro-3β,5β,8,10,13β-Pentahydroxy-11α-Methoxy-6,13-Dimethyl-2α,6α-Epoxy-2H-Naphthaceno[1,2-B]Oxocin-9,16-Dione is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.