Description

1,2-Dipalmitoyl(3,4-Azidosalicylamido)Phosphatidylethanolamine is a specialized, photoactivatable phospholipid derivative designed for advanced bioconjugation and labeling applications. Its core value lies in the unique azidosalicylamido group, which enables efficient, site-specific crosslinking upon UV irradiation, making it a critical tool for probing biomolecular interactions. This compound is essential for researchers and developers in biopharmaceuticals, proteomics, and advanced materials science who require precise and stable modification of lipid membranes, liposomes, or other biological surfaces.

Application

• Liposome and Nanoparticle Surface Functionalization: For creating targeted drug delivery systems with covalently attached ligands, antibodies, or peptides.
• Membrane Protein Labeling and Crosslinking: Used to study protein-protein interactions within lipid bilayers or to immobilize membrane proteins for analytical purposes.
• Bioconjugation Reagent: Acts as a photoactivatable linker for attaching various probes (e.g., fluorescent dyes, biotin, polyethylene glycol) to lipid-containing structures.
• Model Membrane Studies: Employed in the construction of artificial membranes to investigate lipid dynamics, raft formation, and signaling events.
• Diagnostic Assay Development: Facilitates the stable immobilization of capture molecules on lipid-based sensor platforms.
• Materials Science: Used to modify surfaces with biomimetic lipid layers for biocompatible coatings or biosensor interfaces.

Basic Information

Product Name	1,2-Dipalmitoyl(3,4-Azidosalicylamido)Phosphatidylethanolamine
CAS No.	114747-15-8
Molecular Formula	C49H86N5O11P
Molecular Weight	952.20 g/mol
Synonyms	DPPE-ASA; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(3,4-azidosalicylamide); Azidosalicylamidocaproyl DPPE; Photoactivatable DPPE; ASA-DPPE; N-((3,4-Azidosalicyl)amido)caproyl-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; N-[6-[(3,4-Diazido-2-hydroxybenzoyl)amino]hexanoyl]-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl(3,4-Azidosalicylamido)Phosphatidylethanolamine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity, and functional activity. We adhere to cGMP guidelines where applicable to support our clients in regulated preclinical and process development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere (argon or nitrogen) and avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Functional Activity	Photo-crosslinking efficiency confirmed by assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.