Description

Fascaplysin Chloride is a synthetic, heterocyclic alkaloid derivative of significant interest in biochemical research. This compound matters for its potent and selective inhibition of cyclin-dependent kinase 4 (CDK4), a key regulator of the cell cycle. Researchers in the pharmaceutical and biotechnology sectors need it as a critical reference standard and tool compound for investigating cell cycle mechanisms, cancer biology, and developing novel therapeutic agents.

Application

• Biochemical Research: Used as a selective CDK4 inhibitor to study cell cycle progression, cellular senescence, and proliferation pathways in vitro.
• Oncology Research: Serves as a key pharmacological tool for investigating the role of CDK4 in various cancer models, including breast cancer, glioblastoma, and leukemia.
• Drug Discovery & Development: Employed as a reference compound in high-throughput screening (HTS) assays and structure-activity relationship (SAR) studies for novel CDK4/6 inhibitors.
• Academic Research: Utilized in university and institutional labs for fundamental studies in molecular biology, signal transduction, and apoptosis.
• Pharmaceutical Reference Standard: Acts as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Fascaplysin Chloride
CAS No.	114719-57-2
Molecular Formula	C₁₈H₁₁ClN₂O
Molecular Weight	306.75 g/mol
Synonyms	Fascaplysin; Fascaplysin hydrochloride; 12H-Pyrido[1,2-a:3,4-b']diindol-12-one, 5-chloro-; 5-Chloro-12H-pyrido[1,2-a:3,4-b']diindol-12-one; CDK4 Inhibitor II; CAS 114719-57-2 (Chloride salt)
EINECS	Contact for details

Quality Control

Our Fascaplysin Chloride is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Red to dark red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.