Description

24,24-Dihomo-1,25-Dihydroxycholecalciferol is a biologically active vitamin D3 analog with an extended side chain. This compound is of significant interest for its potent role in regulating calcium and phosphate metabolism, offering a high-affinity ligand for the vitamin D receptor (VDR). It is primarily utilized by research institutions and pharmaceutical developers focused on endocrinology, bone health, and novel therapeutic pathways. The product is supplied to meet the stringent requirements of advanced biochemical and pharmacological research.

Application

• Biochemical Research: Used as a high-potency reference standard and ligand in studies of vitamin D receptor (VDR) signaling pathways and gene regulation.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the research and development of novel therapeutics for metabolic bone diseases.
• Endocrinology Studies: Employed in in vitro and in vivo models to investigate calcium homeostasis, bone mineralization, and parathyroid hormone regulation.
• Cell Biology & Differentiation: Utilized to study the effects on cell proliferation and differentiation, particularly in cancer research related to VDR expression.
• Analytical Standard: Acts as a certified reference material for the calibration and validation of analytical methods such as HPLC and LC-MS in quality control laboratories.

Basic Information

Product Name	24,24-Dihomo-1,25-Dihydroxycholecalciferol
CAS No.	114694-09-6
Molecular Formula	C₂₉H₄₆O₃
Molecular Weight	442.67 g/mol
Synonyms	1,25-Dihydroxy-24,24-dihomocholecalciferol; 24,24-Dihomo-1,25-dihydroxyvitamin D3; 24,24-Dihomo-calcitriol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 24,24-dihomo-; 24,24-Bishomo-1,25-dihydroxycholecalciferol; 24,24-Dihomo-1α,25-dihydroxyvitamin D₃; Vitamin D3 analog 24,24-dihomo
EINECS	Contact for details

Quality Control

Our 24,24-Dihomo-1,25-Dihydroxycholecalciferol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere if specified and opened under controlled conditions to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.