Description

n-(Deoxycytidylyl-(3'-5')-Guanosin-8-Yl)Aniline is a specialized, high-purity nucleoside derivative used as a critical building block in advanced biochemical research and development. This compound is essential for scientists working on the synthesis and study of modified oligonucleotides, particularly for investigating DNA damage, adduct formation, and structure-activity relationships. It is primarily utilized by research institutions and pharmaceutical companies focused on oncology, molecular biology, and the development of novel diagnostic probes or therapeutic agents.

Application

• Biochemical Research Reagent: A key intermediate in the synthesis of site-specifically modified oligonucleotides for studying mutagenesis and DNA repair mechanisms.
• Pharmaceutical Development: Used in the research and development of novel chemotherapeutic agents and targeted cancer therapies that involve DNA interaction.
• Molecular Biology Studies: Employed as a probe or standard in assays designed to detect and quantify specific DNA adducts formed by aromatic amines.
• Academic Research: Serves as a critical tool in university and institutional labs for fundamental research into carcinogenesis and genetic toxicology.
• Diagnostic Probe Synthesis: Can be incorporated into oligonucleotide sequences for the development of highly specific diagnostic assays.

Basic Information

Product Name	n-(Deoxycytidylyl-(3'-5')-Guanosin-8-Yl)Aniline
CAS No.	114692-54-5
Molecular Formula	C24H28N9O11P
Molecular Weight	649.52 g/mol
Synonyms	8-(N-Phenylamino)-2'-deoxyguanosine-3',5'-bisphosphate cytidine ester; dCpdG-8-AA; N-(dCpdG-8-yl)aniline; Aniline adduct of dCpdG; 8-(Phenylamino)-2'-deoxyguanosine-3',5'-bisphosphate cytidine ester; DNA adduct CG-8-AA; CG(8-AA)
EINECS	Contact for details

Quality Control

Our n-(Deoxycytidylyl-(3'-5')-Guanosin-8-Yl)Aniline is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment due to its hygroscopic (moisture-sensitive) nature. For long-term storage under inert atmosphere, seal under argon or nitrogen. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.